مرکز تحقیقات شیمی دارویی و گیاهی | Publications
محققان دانشجویاننقشه سایت
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PEER REVIEWED PUBLICATIONS

 

  1. Sertraline Has Anticancer Effects and Enhances the Cytotoxicity of Chemotherapeutic Agents Against Pancreatic Cancer Cells.

Shahrabi, M., Aliparast, A., Moosavi, F., Jafari, A., Firouzabadi, N., Firuzi, O.* (*Corresponding author)

Arch. Pharm. 359(6):e70290 (2026).

 

  1. Synthesis and Biological Evaluations of New 4,5-Diphenyl-Imidazole-Indole-N-Phenylacetamide Derivatives Against α-glucosidase and Acetylcholinesterase.

Ghafouri, S.N., Halimi, M., Dastyafteh, N., Behzad, C., Ebrahimi, S.M., Aghaei Khouzani, M., Noori, M., Aktaş, A., Sadeghian, N., Dadgar, A., Larijani, B., Mohammadi-Khanaposhtani, M., Taslimi, P., Firuzi, O., Mahdavi, M.

Arch. Pharm.  359(6):e70294 (2026).

 

  1. Protein Kinase Inhibitors as Regulators of ABC Transporters in Overcoming Cancer Multidrug Resistance: A Comprehensive Review of Recent Advances.

Moosavi, F., Hassani, B., Mortazavi, M., Peters, G.J., Firuzi, O.* (*Corresponding author)

Cancers 18(12):1957 (2026).

 

  1. Origami Bioinspired Sensor Array Using Nanocluster-Carbon Dot Hybrids for Multiplexed Smell- and Taste-Mimetic Analysis of Blood Plasma in Cancer Detection.

Heidary, O., Shojaeifard, Z., Akhond, M., Fattahi, M.J., Ghaderi, A.A., Firuzi, O., Hemmateenejad, B.

ACS Sens. 11(7):5804-5816 (2026)

 

  1. Diterpenoid compounds isolated from Salvia majdae (Rech.f. & Wendelbo) Sytsma show antiproliferative and apoptosis inducing capacity against cancer cells.

Nazemosadat-Arsanjani, Z., Poustforoosh, A., Pirhadi, S., Choudhary, M.I., Ayatollahi, S.A., Moein, M, Firuzi, O.* (*Corresponding author)

Nat. Prod. Res. 10:1-14 (2026).

 

  1. Design, synthesis, and bioactivity assessment of highly potent isatin-based small-molecules bearing 3-hydrazineyl-6-aryl-1,2,4-triazine moieties as potential c-MET targeting anticancer agents.

Zakeri Khatir, Z., Alipour, A., Mortazavi, M., Tavakkoli, M., Irannejad, H., Foroumadi, A., Firuzi, O.*, Valipour, M. (*Corresponding author)

Bioorg. Chem. 179:109990 (2026).

 

  1. Study of di- (thiophene-2-yl)-1,2,4-triazine derivatives as multikinase inhibitors and anticancer agents.

Mortazavi, M., Edraki, N., Tavakkoli, M., Karimian, S., Saso, L., Firuzi, O.* (*Corresponding author)

J. Mol. Struct. (2026).

 

  1. Expanding the therapeutic applications of PARP inhibitors in cancer by targeting receptor tyrosine kinases.

Jafari, A., Fathi, S., Moosavi, F., Firuzi, O.* (*Corresponding author)

Biochim. Biophys. Acta Rev. Cancer. 1881(3):189552 (2026).

 

  1. Olaparib has synergistic effects with DNA damaging agents in pancreatic ductal adenocarcinoma.

Hassani, B., Jafari, A., Tavakkoli, M., Moosavi, F., Firuzi, O.* (*Corresponding author)

Biochem. Biophys. Res. Commun. 795:153080. (2026)

 

  1. Novel heteroaryl carboxamide derivatives of 5-oxohexahydroquinoline scaffold: Design, synthesis and evaluation of inhibitory profile against MDR1 and BCRP transporters in vitro andin silico.

Shahraki, O., Poustforoosh, A., Miri, R., Khoshneviszadeh, M., Falson, P., Saso, L., Firuzi, O.*, Edraki, N. (*Corresponding author)

J. Mol. Struct. 1348, 143466 (2025).

 

  1. Miniaturized biomimetic taste-smell fusion sensor array for rapid and simultaneous profiling of volatile and non-volatile blood plasma constituents toward identification of head and neck carcinoma and breast cancer.

Heidary, O., Shojaeifard, Z., Akhond, M., Fattahi, M.J., Ghaderi, A., Firuzi, O., Hemmateenejad, B.

Chem. Eng. J. 526:171528 (2025).

 

  1. Spiroindoline quinazolinedione derivatives as inhibitors of P-glycoprotein: potential agents for overcoming multidrug resistance in cancer therapy.

Moosavi, F., Divar, M., Khabnadideh., S, Tavakkoli, M., Mohabbati, M., Saso, L., Poustforoosh, A., Firuzi, O.* (*Corresponding author)

Mol. Divers. Mar 19. (2025).

 

  1. Design, synthesis and pharmacological evaluation of 1,4-naphthoquinone- 1,2,3-triazole hybrids as new anticancer agents with multi-kinase inhibitory activity.

Mardaneh, P., Pirhadi, S., Mohabbati, M., Khoshneviszadeh, M., Rezaei, Z., Saso, L., Edraki, N., Firuzi, O.* (*Corresponding author)

Sci. Rep. 15(1):6639 (2025).

 

  1. Bioassay-Guided Purification of Cytotoxic Isoflavonoids and Sesquiterpenoids of Streptomyces coelicolor Isolated from Marine Sponge Axinella sinoxea, and In Silico Target Prediction.

Alborz, M., Gozari, M., Firuzi, O., Poustforoosh, A., El Seedi, H.R., Jassbi, A.

Iran J Biotechnol. 23(4):e4026 (2025).

 

  1. New benzothiazole-indole-1,2,3-triazole-N-phenylacetamide derivatives as cytotoxic agents: Design, synthesis, and in vitro cytotoxic evaluations       

Taherkhani, A.M., Sayahi, M.H., Hassani, B., Dastyafteh, N., Mohammadi-Khanaposhtani, M., Rafiei E., Meshkani M., Safapoor, S., Mohajeri Tehrani, M., Larijani, B., Mahdavi, M., Firuzi, O.* (*Corresponding author)

J. Mol. Struct. 1336 (2025).

 

  1. Spiroisatin pyranopyrimide derivatives as receptor tyrosine kinase inhibitors and targeted anticancer agents

Alipour A., Farhadi, P., Mobaraki, K., Mardaneh, P., Mohammadi, S., Khoshneviszadeh , M., Pirhadi, S., Poustforoosh, A., Saso, L., Edraki, N., Firuzi, O.* (*Corresponding author)

J. Mol. Struct. 1331:141576 (2025).

 

  1. c-MET tyrosine kinase inhibitors reverse multidrug resistance in breast cancer cells by targeting ABCG2 transporter.

Nazari, S., Mosaffa, F., Poustforoosh, A., Saso, L., Firuzi, O., Moosavi, F.

J. Pharm. Pharmacol. Mar 7:rgaf008 (2025).

 

  1. Combination of chemotherapy and c-MET inhibitors has synergistic effects in c-MET overexpressing pancreatic cancer cells.

Moosavi, F., Firoozi, R., Tavakkoli, M., Nazari, S., Alipour, A., Firuzi, O.* (*Corresponding author)

Biochimie 231:73-83 (2025).

 

  1. N-ethyl morpholine-deca hydroacridine 1, 8-diones as novel P-gp inhibitors and multidrug resistance reversal agents in cancer cells

Eskandari, M., Moosavi, F., Nazari, S., Mardaneh, P., Poustforoosh, A., Zargari, F., Mohabbati, M., Saso, l., Edraki, N., Firuzi, O.* (*Corresponding author)       

J. Mol. Struct. 1325:140953 (2025).

 

  1. New and efficient one-pot method for the synthesis of spiro[indoline-2,1′-isobenzofuran] derivatives and evaluation of their anticancer activity by in vitro and in silico studies

Alborz, M., Mohammadizadeh, M.R., Mardanhe, P., Hassani, B., Mohabbati, M., Firuzi, O.

J. Mol. Struct. 1321:140164 (2025).

 

  1. Novel spiroisatin-pyranopyrazole hybrids as anticancer agents with TrkC inhibitory potential.

Mohammadi, S, Mortazavi, M, Poustforoosh, A, Moosavi, F, Saso, L, Edraki, N, Firuzi, O.* (*Corresponding author)

J. Biomol. Struct. Dyn. Mar 2:1-14 (2025).

 

  1. c-MET tyrosine kinase inhibitors reverse drug resistance mediated by the ATP-binding cassette transporter B1 (ABCB1) in cancer cells.

Nazari, S., Poustforoosh, A., Paul, P.R., Kukreti, R., Tavakkoli, M., Saso, L., Firuzi, O., Moosavi F.

3 Biotech. 15(1):2 (2025).

 

  1. Design, synthesis, and cytotoxic activity of 2-amino-1,4-naphthoquinone-benzamide derivatives as apoptosis inducers.

Sayahi, M.H., Hassani, B., Mohammadi-Khanaposhtani, M., Dastyafteh, N., Gohari, M.R., Tehrani, M.M., Larijani, B., Mahdavi, M., Firuzi, O.* (*Corresponding author)

Sci Rep. 14(1):27302 (2024).

 

  1. Synthesis and cytotoxic activity evaluation of novel imidazopyridine carbohydrazide derivatives.

Firouzi, M., Haghighijoo, Z., Eskandari, M., Mohabbati, M., Miri, R., Jamei, M.H., Poustforoosh, A., Nazari, S., Firuzi, O., Khoshneviszadeh, M., Edraki, N.

BMC Chem. 18(1):6 (2024).

 

  1. Targeting DNA damage response in pancreatic ductal adenocarcinoma: A review of preclinical and clinical evidence.

Moosavi, F., Hassani, B., Nazari, S., Saso, L., Firuzi, O.* (*Corresponding author)

Biochim. Biophys. Acta Rev. Cancer 1879(6):189185 (2024).

 

  1. Foretinib, a c-MET receptor tyrosine kinase inhibitor, tackles multidrug resistance in cancer cells by inhibiting ABCB1 and ABCG2 transporters.

Nazari, S., Mosaffa, F., Poustforoosh, A., Mortazavi, M., Saso, L., Firuzi, O., Moosavi, F.

Toxicol. Appl. Pharmacol. 2024 15:116866 (2024).

 

  1. A Fluorescent Furan-based Probe with Protected Functional Groups for Highly Selective and Non-Toxic Imaging of HT-29 Cancer Cells and 4T1 Tumors.

Naderi, P.M., Zargoosh, K., Qandalee, M., Firuzi, O., Behmadi, H., Hosseinkhani, S., Ghafary S.M., Durán-Valle C.J., López-Coca I.M.

Chempluschem. 89(9):e202400095 (2024).

 

  1. Cytidine deaminase enzyme activity is a predictive biomarker in gemcitabine-treated cancer patients.

Abbaspour, A., Dehghani, M., Setayesh, M., Tavakkoli, M., Rostamipour, H.A., Ghorbani, M., Ramzi, M., Omidvari, S., Moosavi, F., Firuzi, O.* (*Corresponding author)

Cancer Chemother. Pharmacol. 92(6):475-483 (2023).

 

  1. Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties.

Mortazavi, M., Eskandari, M., Moosavi, F., Damghani, T., Khoshneviszadeh, M., Pirhadi, S., Saso, L., Edraki, N., Firuzi, O.* (*Corresponding author)

Sci. Rep. 13(1):14685 (2023).

 

  1. 5-Oxohexahydroquinolines bearing 4-pyridyl methyl carboxylate as P-glycoprotein inhibitors and multidrug resistance reversal agents in cancer cells.

Ranjbar, S., Lashkarian, F.F., Khoshneviszadeh, M., Moosavi, F., Damghani, T., Firuzi, O.*, Edraki, N. (*Corresponding author)

J. Mol. Struct. 1285:135427 (2023).

 

  1. Novel spiroindoline quinazolinedione derivatives as anticancer agents and potential FLT3 kinase inhibitors.

Divar, M., Edraki, N., Damghani, T., Moosavi, F., Mohabbati, M., Alipour, A., Pirhadi, S., Saso, L., Khabnadideh, S., Firuzi, O.* (*Corresponding author)

Bioorg. Med. Chem. 15(90):117367 (2023).

 

  1. Targeted co-delivery of paclitaxel and anti P-gp shRNA by low molecular weight PEI decorated with L-3,4-dihydroxyphenylalanine

Kazemi, M., Parhizkar, E., Samani, S.M., Firuzi, O., Sadeghpour, H., Ahmadi, F., Dehshahri, A.

Biotechnol. Prog. 39(2):e3310 (2023).

 

  1. Sappanin-type homoisoflavonoids from Scilla bisotunensis Speta.: Cytotoxicity, molecular docking, and chemotaxonomic significance.

Hafez Ghoran, S., Firuzi, O., Pirhadi, S., Khattab, O.M., El-Seedi, H.R., Jassbi, A.R.

J. Mol. Struct. 127:134326 (2023).

 

  1. Discovery of anticancer agents with c-Met inhibitory potential by virtual and experimental screening of a chemical library.

Mortazavi, M., Raufi, E., Damghani, T., Khoshneviszadeh, M., Edraki, N., Eskandari, M., Giovannetti, E., Peters, G.J., Pirhadi, S., Firuzi, O.* (*Corresponding author)

Eur. J. Pharmacol. 938:75395 (2023).

 

  1. Acenaphthotriazine Thio-triazole Derivatives as Anti-cancer Agents Triggering Cell Cycle Arrest in Breast Cancer Cells.

Iraji, I., Shahrokh, N., Firuzi, O., Mohabbati, M., Miri, M., Sadeghpour, H., Khoshneviszadeh, M., Edraki, N.

Lett. Drug Des. Discov. 20(6):639-648 (2023).

 

  1. Cinnamomum verum J. Presl. Bark essential oil: in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity.

Saeedi, M., Iraji, A., Vahedi-Mazdabadi, Y., Alizadeh, A., Edraki, N., Firuzi, O., Eftekhari, M., Akbarzadeh, T.

BMC Complement. Med. Ther. 22(1):303 (2022).

 

  1. Reassessing the molecular structures of some previously isolated abietane diterpenoids with a naphthalene moiety and the structure-activity relationship (SAR) of quinone diterpenoids.

Nazemosadat-Arsanjani, Z., Moein, M., Yousuf, S., Firuzi, O., Choudhary, M.I.

Phytochemistry. 204:113433 (2022).

 

  1. Phytochemical Analysis and Biological Activity of Salvia compressa Vent

Noorbakhsh, F., Zare, S., Firuzi, O., Sakhteman, A., Chandran, J.N., Schneider, B., Jassbi, A.R.

Iran. J Pharm. Res. 21(1):e127031 (2022).

 

  1. Study of the anticancer effect of new quinazolinone hydrazine derivatives as receptor tyrosine kinase inhibitors.

Mortazavi M, Divar M, Damghani T, Moosavi F, Saso L, Pirhadi S, Khoshneviszadeh M, Edraki N, Firuzi, O.* (*Corresponding author)

Front. Chem. 2022 10:969559 (2022).

 

  1. Synthesis and application of the fluorescent furan and imidazole probes for selective in vivo and in vitro cancer cell imaging.

Mehdizadeh Naderi, P., Zargoosh, K., Qandalee, M., Firuzi, O., Behmadi, H., Hossienkhani, S., Moasses Ghafary, S., Durán-Valle, C.J.

Spectrochim. Acta A. Mol. Biomol. Spectrosc. 279:121455 (2022).

 

 

  1. Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer.

Mortazavi, M., Moosavi, F., Martini, M., Giovannetti, E., Firuzi, O.* (*Corresponding author)

Crit. Rev. Oncol. Hematol. 176:103749 (2022).

 

  1. 5-Oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridine derivatives as promising antiproliferative agents with potential apoptosis-inducing capacity.

Ranjbar, S., Khoshneviszadeh, M., Tavakkoli, M., Miri, R., Edraki, N., Firuzi, O.* (*Corresponding author)

Mol. Divers. 26(3):1481-1500 (2022).

 

  1. Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer’s disease.

Rastegari, A., Safavi, M., Vafadarnejad, F., Najafi, Z., Hariri, R., Bukhari, S.N.A., Iraji, A., Edraki, N., Firuzi, O., Saeedi, M., Mahdavi, M., Akbarzadeh, T.     

Mol. Divers. 26(1):409-428 (2022).

 

  1. Imino-2H-Chromene Based Derivatives as Potential Anti-Alzheimer's Agents: Design, Synthesis, Biological Evaluation andin SilicoStudy.

Attarroshan, M., Firuzi, O., Iraji, A., Sharifi, S., Tavakkoli, M., Vesal M., Khoshneviszadeh M., Pirhadi, S., Edraki, N.

Chem. Biodivers. 16:e2100599 (2022).

 

  1. Cytotoxic abietane-type diterpenoids from roots ofSalvia spinosaand theirin Silicopharmacophore modeling.

Jassbi, A.R., Hadavand Mirzaei, H., Firuzi, O., Pirhadi, S., Asadollahi, M., Chandran, J.N., Schneider, B.

Nat. Product. Res. 22:1-6 (2022).

 

  1. Cytotoxic furanosesquiterpenoids and steroids from Ircinia mutans sponges.

Heidary Jamebozorgi, F., Yousefzadi, M., Firuzi, O., Nazemi, M., Zare, S., Chandran, J.N., Schneider, B., Baldwin, I.T., Jassbi, A.R.

Pharm. Biol. 59(1):575-583 (2021).

 

  1. Phenanthrotriazine Derivatives Containing Arylidine Hydrazone Moieties as Novel Potential c-Met Inhibitors with Anticancer Effect.

Edraki N., Jamei M.H., Haghighijoo Z., Kayani Z., Raufi E., Eskandari M., Firouzi M., Sadeghpour H., Miri R., Khoshneviszadeh M., Firuzi, O.* (*Corresponding author)

Iran. J. Pharm. Res. 20: 516-531 (2021).

 

  1. Novel Cytotoxic Phenanthro-triazine-3-thiol Derivatives as Potential DNA Intercalators and Bcl-2 Inhibitors.

Khoshneviszadeh, M., Firuzi, O., Aminsafaee, M., Kashefizadeh, M., Ranjbar, S., Rezaei, Z., Sadeghpour, H., Zargari, F., Miri, R., Edraki, N.

Iran. J. Pharm. Res. 20(3):161-177 (2021).

 

  1. Assessment of Phenolic Contents and Antibacterial, Cytotoxic, and Antioxidant Activities of Five Brown Algae from the Persian Gulf.

Moheimanian, N., Firuzi, O., Sohrabipour, J., Jassbi, A.R.       

Iran. J. Sci. Technol. Transact. A: Sci. 45:1869-1877 (2021).

 

  1. Imidazopyridine hydrazine derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c‑Met.

Damghani, T., Moosavi, F., Khoshneviszadeh, M., Mortazavi, M., Pirhadi, S., Kayani, Z., Saso, L., Edraki, N., Firuzi, O.* (*Corresponding author)

Sci. Rep. 11:3644 (2021).

 

  1. Synthesis and bio-evaluation of new multifunctional methylindolinone-1,2,3-triazole hybrids as anti-Alzheimer's agents.

Saeedi, M., Maleki, A., Iraji, A., Hariri, R., Akbarzadeh, T., Edraki, N., Firuzi, O., Mirfazli, S.  

J. Mol. Struct. 1229:129828 (2021).

 

  1. Combination of HGF/MET-targeting agents and other therapeutic strategies in cancer.

Moosavi, F., Giovannetti, E., Peters, G.J., Firuzi, O.* (*Corresponding author)

Crit. Rev. Oncol. Hematol. 160:103234 (2021).

 

  1. Dammarane-type triterpenoid saponins fromSalvia russelliiBenth.

Hafez Ghoran, S., Firuzi, O., Asadollahi, M., Stuppner, H., Alilou, M., Jassbi, A.R.     

Phytochemistry 184:112653 (2021).

 

  1. Antileishmanial and pharmacophore modeling of abietane-type diterpenoids extracted from the roots ofSalvia hydrangea.

Zare, S., Hatam, G., Firuzi, O., Bagheri, A., Chandran, J.N., Schneider, B., Paetz, C., Pirhadi, S., Jassbi, A.R.          

J. Mol. Struct. 1228:129447 (2021).

 

  1. Antiproliferative effect, alteration of cancer cell cycle progression and potential MET kinase inhibition induced by 3,4-dihydropyrimidin-2(1H)-one C5 amide derivatives.

Moosavi, F., Ebadi, A., Mohabbati, M., Damghani, T., Mortazavi, M., Miri, R., Firuzi, O.* (*Corresponding author)

Eur. J. Pharmacol. 894:173850 (2021).

 

  1. Novel N-benzylpiperidine derivatives of 5-arylisoxazole-3-carboxamides as anti-Alzheimer's agents.

Saeedi, M., Felegari, P., Iraji, A., Hariri, R., Rastegari, A., Mirfazli, S.S., Edraki, N., Firuzi, O., Mahdavi, M., Akbarzadeh, T.

Arch. Pharm. 354(3):2000258 (2021).

 

  1. Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.

Viayna, E., Coquelle, N., Cieslikiewicz-Bouet, M., Cisternas, P., Oliva, C.A., Sánchez-López, E.f, Ettcheto, M., Bartolini, M., De Simone, A., Ricchini, M., Rendina, M., Pons, M., Firuzi, O., Pérez, B., Saso, L., Andrisano, V., Nachon, F., Brazzolotto, X., García, M.L., Camins, A., Silman, I., Jean, L., Inestrosa, N.C., Colletier, J.-P., Renard, P.-Y., Muñoz-Torrero, D.

J. Med. Chem. 64(1):812-839 (2021).

 

  1. 5-Oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridine derivatives as promising antiproliferative agents with potential apoptosis-inducing capacity

Ranjbar, S., Khoshneviszadeh, M., Tavakkoli, M., Miri, R., Edraki, N., Firuzi, O.* (*Corresponding author)

Mol. Divers. (2021).

 

 

  1. Dihydronaphthalenone chalconoid derivatives as potential cathepsin b inhibitors; design, synthesis, cytotoxicity evaluation and docking analysis.

Ranjbar, S., Shabanpoor, M.R., Dehghani, Z., Firuzi, O., Edraki, N., Khoshneviszadeh, M.Braz. J. Pharm. Sci.57:18074 (2021).

 

  1. Paclitaxel-loaded polypeptide-polyacrylamide nanomicelles overcome drug-resistance by enhancing lysosomal membrane permeability and inducing apoptosis.

Abbasi, S., Yousefi, G., Tamaddon, A.M., Firuzi, O.

J. Biomed. Mater. Res. A. 109(1):18-30 (2021).

 

  1. Design and synthesis of novel 1-hydroxy-2,4,5-triaryl imidazole derivatives as anti-cytokine agents.

Haghighijoo, Z., Firuzi, O., Meili, S., Edraki, N., Khoshneviszadeh, M., Miri, R.

Iran. J. Pharm. Res. 19(1):181-191 (2020).

 

  1. Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease.

Karimi Askarani, H., Iraji, A., Rastegari, A., Abbas Bukhari, S., Firuzi, O., Akbarzadeh, T., Saeedi, M.

BMC Chem. 14(1):64 (2020).

 

  1. Antidiabetic and cytotoxic polyhydroxylated oleanane and ursane type triterpenoids from Salvia grossheimii.

Zare, S., Mirkhani, H., Firuzi, O., Moheimanian, N., Asadollahi, M., Pirhadi, S., Chandran, J.N., Schneider, B., Jassbi, A.R.

Bioorg. Chem. 104:104297 (2020).

 

  1. Thieno[2,3-b]pyridine amines: Synthesis and evaluation of tacrine analogs against biological activities related to Alzheimer's disease.

Saeedi, M., Safavi, M., Allahabadi, E., Rastegari, A., Hariri, R., Jafari, S., Bukhari, S.N.A., Mirfazli, S.S., Firuzi, O., Edraki, N., Mahdavi, M., Akbarzadeh, T.

Arch. Pharm. 353(10):2000101 (2020).

 

  1. Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models.

Che, P.P., Gregori, A., Firuzi, O., Dahele, M., Sminia, P., Peters, G.J. Giovannetti, E.

Exp. Hematol. Oncol. 9:18 (2020).

 

  1. 5,6-Diphenyl triazine-thio methyl triazole hybrid as a new Alzheimer's disease modifying agents.

Yazdani, M., Edraki, N., Badri, R., Khoshneviszadeh, M., Iraji, A., Firuzi, O.

Mol. Divers. 24(3):641-654 (2020).

 

  1. Design and synthesis of novel arylisoxazole-chromenone carboxamides: Investigation of biological activities associated with Alzheimer's disease.

Saeedi, M., Rastegari, A., Hariri, R., Mirfazli, S.S., Mahdavi, M., Edraki, N., Firuzi, O., Akbarzadeh, T.

Chem. Biodivers. 17(5):e1900746 (2020).

 

  1. Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands.

Iraji, A., Khoshneviszadeh, M., Firuzi, O., Khoshneviszadeh, M., Edraki N.

Bioorg. Chem. 97:103649 (2020).

 

  1. Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention.

Cunha-Oliveira, T., Montezinho, L., Mendes, C., Firuzi, O., Saso, L., Oliveira, P.J., Silva, F.S.G.

Oxid. Med. Cell. Longev. 2020:5021694 (2020).

 

  1. 5-Oxo-hexahydroquinoline derivatives and their tetrahydroquinoline counterparts as multidrug resistance reversal agents.

Shahraki, O., Khoshneviszadeh, M., Dehghani, M., Mohabbati, M., Tavakkoli, M., Saso, L., Edraki, N., Firuzi, O.* (*Corresponding author)

Molecules 25(8). pii: E1839. (2020).

 

  1. Study of the mechanism of action, molecular docking, and dynamics of anticancer terpenoids fromSalvia lachnocalyx.

Hadavand Mirzaei, H., Jassbi, A.R., Pirhadi, S., Firuzi, O.* (*Corresponding author)

J. Recept. Signal. Transduct. Res. 40(1):24-33 (2020).

 

  1. Phytoconstituents from the aerial parts ofSalvia dracocephaloidesboiss. and their biological activities.

Ghoran, S.H., Firuzi, O., Jassbi, A.R.

J. Environ. Treat. Tech. 8(4):1274-1278 (2020)

 

  1. Synthesis and in vitro biological activity evaluation of novel imidazo [2,1-B][1,3,4] thiadiazole as anti-Alzheimer agents.

Azimi, S., Firuzi, O., Iraji, A., Zonouzi, A., Khoshneviszadeh, M., Mahdavi, M., Edraki, N.

Lett. Drug Des. Discov. 17(5):608-615 (2020).

 

  1. Cytotoxic activity and DNA binding property of new aminopyrimidine derivatives.

Akrami, H., Mirjalili, B., Firuzi, O., Hekmat, A., Sab-Oury, A.A., Miri, R., Sabzevari, O., Pirali-Hamedani, M., Jeivad, F., Moghimi, S., Emami, S., Foroumadi, A., Khoobi, M.

Lett. Drug Des. Discov. 17(5):638-652 (2020).

 

  1. Caffeic acid alkyl amide derivatives ameliorate oxidative stress and modulate ERK1/2 and Akt signaling pathways in a rat model of diabetic retinopathy.

Fathalipour, M., Eghtedari, M., Borges, F., Silva, T., Moosavi, F., Firuzi, O., Mirkhani, H.

Chem. Biodivers. 16(12):e1900405 (2019).

 

  1. HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers.

Moosavi, F., Giovannetti, E., Saso, L., Firuzi, O.* (*Corresponding author)

Crit. Rev. Clin. Lab. Sci. 12:1-34 (2019).

 

  1. Novel N-benzylpyridinium moiety linked to arylisoxazole derivatives as selective butyrylcholinesterase inhibitors: Synthesis, biological evaluation, and docking study.

Vafadarnejad, F., Karimpour-Razkenari, E., Sameem, B., Saeedi, M., Firuzi, O., Edraki, N., Mahdavi, M., Akbarzadeh, T.

Bioorg. Chem. 92:103192 (2019).

 

  1. Ethnopharmacological studies, chemical composition, antibacterial and cytotoxic activities of essential oils of elevenSalviain Iran.

Asadollahi, M., Firuzi, O., Heidary Jamebozorgi, F., Alizadeh, M., Jassbi, A.R.

J. Herb. Med. 17-18:100250 (2019).

 

  1. Prediction of cytotoxic activity of a series of 1H-pyrrolo[2,3-b]pyridine derivatives as possible inhibitors of c-Met using molecular fingerprints.

Damghani, T., Mashayekh, K., Pirhadi, S., Firuzi, O., Sharifi, S., Edraki, N., Khoshneviszadeh, M., Avestan, M.S.

J. Recept. Signal Transduct. Res. 28:1-9 (2019).

 

  1. Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations.

Gholampour, M., Ranjbar S., Edraki, N., Mohabbati M., Firuzi O., Khoshneviszadeh, M.

Bioorg. Chem. 88:102967 (2019).

 

  1. In vitro anti-proliferative activities of the sterols and fatty acids isolated from the Persian Gulf sponge;Axinella sinoxea.

Heidary Jamebozorgi, F., Yousefzadi, M., Firuzi, O., Nazemi, M., Jassbi, A.R.

DARU J. Pharmac. Sci. 27:121-135 (2019).

 

  1. 5-Oxo-hexahydroquinoline: an attractive scaffold with diverse biological activities.

Ranjbar, S., Edraki, N., Firuzi, O., Khoshneviszadeh, M., Miri, R.

Mol. Divers. 23:471-508 (2019).

 

  1. Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells.

Firuzi, O., Che, P.P., El Hassouni, B., Buijs, M., Coppola, S., Löhr, M., Funel, N., Heuchel, R., Carnevale, I., Schmidt, T., Mantini, G., Avan, A., Saso, L., Peters, G.J., Giovannetti, E.

Cancers 11(5):638 (2019).

 

  1. Synthesis and biological activity of some benzochromenoquinolinones: Tacrine analogues as potent anti-Alzheimer's agents.

Mahdavi, M., Hariri, R., Mirfazli, S.S., Lotfian, H., Rastergari, A., Firuzi, O., Edraki, N., Larijani, B., Akbarzadeh, T., Saeedi, M.

Chem. Biodivers. 16(4):e1800488 (2019).

 

  1. Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 1,2,4-triazine scaffold containing pendant phenoxy methyl-1,2,3-triazole: Design, synthesis and biological evaluation.

Yazdani, M., Edraki, N., Badri, R., Khoshneviszadeh, M., Iraji, A., Firuzi, O.

Bioorg. Chem. 84:363-371 (2019).

 

  1. Reversing multi-drug tumor resistance to Paclitaxel by well-defined pH-sensitive amphiphilic polypeptide block copolymers via induction of lysosomal membrane permeabilization.

Mostoufi, H., Yousefi, G., Tamaddon, A.M., Firuzi, O.

Colloids Surf. B Biointerfaces. 174:17-27 (2019).

 

  1. Two antiproliferative seco-4,5-abietane diterpenoids from roots ofSalvia ceratophyllaL.

Hadavand Mirzaei, H., Firuzi, O., Chandran, J.N., Schneider, B., Jassbi, A.R.

Phytochem. Lett. 29:129-133 (2019).

 

  1. Design and synthesis of selective acetylcholinesterase inhibitors: arylisoxazole-phenylpiperazine derivatives.

Saeedi, M., Mohtadi-Haghighi, D., Mirfazli, S.S., Mahdavi, M., Hariri, R., Lotfian, H., Edraki, N., Iraji, A., Firuzi, O., Akbarzadeh, T.

Chem. Biodivers. 16:e1800433 (2019).

 

  1. Behaviour of 9-Ethyl-9H-carbazole hydrazone derivatives against oxidant systems: Protective effect on amyloid β-induced damage.

Karaaslan, C., Ince, E., Gurer-Orhan, H., Tavakkoli, M., Firuzi, O., Saso, L., Suzen, S.

Croat. Chem. Acta 92:87-94 (2019).

 

  1. Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds.

Gaspar, A., Mohabbati, M., Cagide, F., Razzaghi-Asl, N., Miri, R., Firuzi, O.*, Borges, F. (*Corresponding author)

Res. Pharm. Sci. 14(1):74-83 (2019).

 

  1. Unsymmetric dihydropyridines bearing 2-pyridyl methyl carboxylate as modulators of P-glycoprotein; Synthesis and biological evaluation in resistant and non-resistant cancer cells.

Nejati, M., Sadeghpour, H., Ranjbar, S., Javidnia, K., Edraki, N., Saso, L. Firuzi, O.*, Miri, R. (*Corresponding author)

Can. J. Chem. 97(8):603-614 (2019).

 

  1. 5-Oxo-hexahydroquinoline derivatives as modulators of P-gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells.

Ranjbar, S., Khonkarn, R., Moreno, A., Baubichon-Cortay, H., Miri, R., Khoshneviszadeh, M., Saso, L., Edraki, N., Falson, P., Firuzi, O.* (*Corresponding author)

Toxicol. Appl. Pharmacol. 362:136-149 (2019).

 

  1. Investigation of polysaccharide extracts from Iranian and French strains of Agaricus subrufescens against enzymes involved in Alzheimer’s disease.

Rahmani-Nezhad, S., Dianat, S., Mahdizadeh, V., Fooladi, Z., Hariri, R., Najafi, Z., Firuzi, O., Vahedi-Mazdabadi, Yg, Farjadmand, F., Akbarzadeh, T., Saeedi, M. Ardekani, M.S.

Latin Am Carib Bull Med Arom Plant 18(6):544-554 (2019).

 

  1. Modulation of ERK1/2 and Akt Pathways Involved in the Neurotrophic Action of Caffeic Acid Alkyl Esters.

Hosseini, R., Moosavi, F., Silva, T., Rajaian, H., Hosseini, S.Y., Bina, S., Saso, L., Miri, R., Borges, F., Firuzi, O.* (*Corresponding author)

Molecules 23:3340 (2018).

 

  1. Novel folic acid-conjugated doxorubicin loaded β-lactoglobulin nanoparticles induce apoptosis in breast cancer cells.

Kayani, Z., Bordbar, A.-K., Firuzi, O.* (*Corresponding author)

Biomed. Pharmacother. 107:945-956 (2018).

 

  1. Assessment of cytotoxicity of choline chloride-based natural deep eutectic solvents against human HEK-293 cells: A QSAR analysis.

Ahmadi, R., Hemmateenejad, B., Safavi, A., Shojaeifard, Z., Mohabbati, M., Firuzi, O.

Chemosphere 209:831-838 (2018).

                                     

  1. Structural Insight into Binding Mode of 9-Hydroxy Aristolochic Acid, Diclofenac and Indomethacin to PLA2.

Ebrahimi, M., Firuzi, O., Miri, R., Razzaghi-Asl, N., Ebadi, A.

Interdiscip. Sci. Comput. Life Sci. 10:400-410 (2018).

 

  1. Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease.

Iraji, A., Firuzi, O., Khoshneviszadeh, M., Nadri, H., Edraki, N., Miri, R.

Bioorg. Chem. 77:223-235 (2018).

 

  1. Doughnut-shaped bovine serum albumin nanoparticles loaded with doxorubicin for overcoming multidrug-resistant in cancer cells.

Kayani, Z., Firuzi, O.*, Bordbar, A.K. (*Corresponding author)

Int. J. Biol. Macromol. 107:1835-1843 (2018).

 

  1. Molecular dynamics simulation and molecular docking studies of 1,4-Dihydropyridines as P-glycoprotein’s allosteric inhibitors.

Shahraki, O., Zargari, F., Edraki, N., Khoshneviszadeh, M., Firuzi, O., Miri, R.

J. Biomol. Struct. Dyn. 36(1):112-125 (2018).

 

  1. Composition and cytotoxic activity of the essential oils of Mentha mozaffarianii Jamzad at different phenological stages.

Jassbi, A.R., Mirzaie, Y., Firuzi, O., Asadollahi, M.

Curr. Bioact. Comp. 14(2):191-196 (2018).

 

  1. 6-Methoxy-3,4-dihydronaphthalenone chalcone-like derivatives as potent tyrosinase inhibitors and radical scavengers.

Ranjbar, S., Akbari, A., Edraki, N., Khoshneviszadeh, M., Hemmatian, H., Firuzi, O., Khoshneviszadeh, M.

Lett. Drug Des. Discov. 15:1170-1179 (2018).

 

  1. Multifunctional iminochromene-2H-carboxamide derivatives containing different aminomethylene triazole with BACE1 inhibitory, neuroprotective and metal chelating properties targeting Alzheimer's disease.

Iraji, A., Firuzi, O., Khoshneviszadeh, M., Tavakkoli, M., Mahdavi, M., Nadri, H., Edraki, N., Miri, R.

Eur. J. Med. Chem. 141:690-702 (2017).

 

  1. Synthesis and biological evaluation of quinazolinone-based hydrazones with potential use in Alzheimer's disease.

Haghighijoo, Z., Firuzi, O., Hemmateenejad, B., Emami, S., Edraki, N., Miri, R.

Bioorg. Chem. 74:126-133 (2017).

 

  1. Long Chain Alkyl Esters of Hydroxycinnamic Acids as Promising Anticancer Agents: Selective Induction of Apoptosis in Cancer Cells.

Menezes, J.C.J.S., Edraki, N, Kamat, SP, Khoshneviszadeh, M, Kayani, Z, Mirzaei, H.H., Miri, R., Erfani, N, Nejati, M., Cavaleiro, J.A.S., Silva, T., Saso, L., Borges, F., Firuzi, O.* (*Corresponding author)

J. Agric. Food Chem. 65(33):7228-7239 (2017).

 

  1. 3,4-Dihydropyrimidin-2(1H)-one C5 amides as inhibitors of TNFα production: Synthesis, biological evaluation and molecular modeling.

Ebadi, A., Khoshneviszadeh, M., Javidnia, K., Ghahremani, M.H., Firuzi, O.*, Miri, R. (*Corresponding author)

Lett. Drug Des. Discov. 14(8): 885-897 (2017).

 

  1. Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer.

Giovannetti, E., van der Borden, C.L., Frampton, A.E., Ali, A., Firuzi, O., Peters, G.J.

Semin. Cancer Biol. 44:43-59 (2017).

 

  1. Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro p-glycoprotein mediated multidrug resistance (MDR) reversal profile and molecular dynamics simulation study.

Shahraki, O., Edraki, N., Khoshneviszadeh, M., Zargari, F., Ranjbar, S., Saso, L., Firuzi, O.*, Miri, R. (*Corresponding author)

Drug Des. Devel. Ther. 11:407-418 (2017).

 

  1. Pegylated and amphiphilic Chitosan coated manganese ferrite nanoparticles for pH-sensitive delivery of methotrexate: Synthesis and characterization.

Karimi, Z., Abbasi, S., Shokrollahi, H., Yousefi, G., Fahham, M., Karimi, L., Firuzi, O.

Mater. Sci. Eng. C 71(1):504-511 (2017).

 

  1. Cytotoxic activities of different Iranian Solanaceae and Lamiaceae plants and bioassay-guided study of an active extract fromSalvia lachnocalyx.

Mirzaei, H.H., Firuzi, O., Baldwin, I.T., Jassbi, A.R.

Nat. Prod. Comm. 12(10):1563-1566 (2017).

 

  1. Cytotoxic diterpenoids from the roots of salvia lachnocalyx.

Mirzaei, H.H., Firuzi, O., Schneider, B., Baldwin, I.T., Jassbi, A.R.

Braz. J. Pharmacogn. 27(4): 475-479 (2017).

 

  1. Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis.

Azimi, S., Zonouzi, A., Firuzi, O., Iraji, A., Saeedi, M., Mahdavi, M., Edraki, N.

Eur. J. Med. Chem. 138:729-737 (2017).

 

  1. Tetrahydroquinolinone derivatives as potent P-glycoprotein inhibitors: Design, synthesis, biological evaluation and molecular docking analysis.

Ranjbar, S., Firuzi, O., Edraki, N., Shahraki, O., Saso, L., Khoshneviszadeh, M. Miri, R.

MedChemComm. 8(10):1919-1933 (2017).

 

  1. Synthesis and cytotoxicity of novel thioxo-quinazolino[3,4-a]quinazolinones

Mohammadhosseini, N., Saeedi, M., Moradi, S., Mahdavi, M., Firuzi, O., Foroumadi, A., Shafiee, A.

Turk. J. Chem. 41:125-134 (2017).

 

  1. Derivatives of caffeic acid, a natural antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic agents.

Moosavi, F., Hosseini, R., Rajaian, H., Silva, T., Magalhães E Silva, D., Saso, L., Edraki, N., Miri, R., Borges, F., Firuzi, O.* (*Corresponding author)

Bioorg. Med. Chem. 25(12): 3235-3246 (2017).

 

  1. Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives as Anticancer Agents.

Rezaei, Z., Moghimi, S., Javaheri, R., Asadi, M., Mahdavi, M., Shabani, S., Edraki, N., Firuzi, O., Safavi, M., Amini, M., et al.

Lett. Drug Des. Discov. 14(10):1138-1144 (2017).

 

  1. Oxidative stress and antioxidants in neurological diseases: is there still hope?

Carvalho, A.N., Firuzi, O., Gama, M.J., van Horssen, J., Saso, L.

Curr. Drug Targets 18(6):705-718 (2017).

 

  1. 2-Imino 2H-chromene and 2-(phenylimino) 2H-chromene 3-aryl carboxamide derivatives as novel cytotoxic agents: synthesis, biological assay, and molecular docking study.

Edraki, N., Iraji, A., Firuzi, O., Fattahi, Y., Mahdavi, M., Foroumadi, A., Khoshneviszadeh, M., Shafiee, A., Miri, R.

J. Iran. Chem. Soc. 13(12):2163-2171 (2016).

 

  1. Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold.

Hosseini, R., Moosavi, F., Rajaian, H., Silva, T., Magalhães E Silva, D., Soares, P., Saso, L., Edraki, N., Miri, R., Borges, F., Firuzi, O.* (*Corresponding author)

Chem. Biol. Drug Des. 88(6):926-937 (2016).

 

  1. Bioassay guided purification of cytotoxic natural products from a red algaDichotomaria obtusata.

Jassbi, A.R., Mirzaei, Y., Firuzi, O., Chandran, J.N., Schneider, B.

Braz. J. Pharmacog. 26(6):705-709 (2016).

 

  1. Structure-based design, synthesis, molecular docking study and biological evaluation of 1,2,4-triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant activities.

Khoshneviszadeh, M., Shahraki, O., Khoshneviszadeh, M., Foroumadi, A., Firuzi, O., Edraki, N., Nadri, H., Moradi, A., Shafiee, A., Miri, R.

J. Enzyme Inhib. Med. Chem. 31(6):1602-1611 (2016).

 

  1. Cytotoxic activity and chemical constituents ofAnthemis mirheydari.

Jassbi, A.R., Firuzi, O., Miri, R., Salhei, S., Zare, S., Zare, M., Masroorbabanari, M., Chandran, J.N, Schneider, B., Baldwin, I.T.

Pharm. Biol.54(10): 2044-2049 (2016).

 

  1. Bioactive phytochemicals from shoots and roots ofSalviaspecies.

Jassbi, A.R., Zare, S., Firuzi, O., Xiao, J.

Phytochem. Rev. 15(5):829-867 (2016).

 

  1. Effects of silymarin on biochemical and oxidative stress markers in end-stage renal disease patients undergoing peritoneal dialysis.

Firuzi, O., Khajehrezaei, S., Ezzatzadegan, S., Nejati, M., Jahanshahi, K., Roozbeh, J.

Hemodial. Int. 20:558–563 (2016).

 

  1. Neuroprotective and Antioxidant Activities of 4-Methylcoumarins: Development of Structure-Activity Relationships.

Malhotra, S., Tavakkoli, M., Edraki, N., Miri, R., Sharma, S.K., Prasad, A.K., Saso, L., Len, C., Parmar, V.S., Firuzi, O.* (*Corresponding author)

Biol. Pharm. Bull. 39(9):1544-1548 (2016).

 

  1. Assessment of the cytotoxic effect of a series of 1,4-dihydropyridine derivatives against human cancer cells.

Razzaghi-Asl, N., Miri, R., Firuzi, O.* (*Corresponding author)

Iran. J. Pharm. Res.15(3):413-420 (2016).

 

  1. Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage.

Gurer-Orhan, H., Karaaslan, C., Ozcan, S., Firuzi, O., Tavakkoli, M., Saso, L., Suzen, S.

Bioorg. Med. Chem. 24(8):1658-1564 (2016).

 

  1. Design and cell cytotoxicity assessment of palmitoylated polyethylene glycol-grafted chitosan as nanomicelle carrier for paclitaxel.

Abbasi, S., Yousefi, G., Firuzi, O., Mohammadi-Samani, S.

J. Appl. Polymer Sci. 133(13):43233 (2016).

 

  1. Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents.

Almasirad, A., Firoozpour, L., Nejati, M., Edraki, N., Firuzi, O., Khoshneviszadeh, M., Mahdavi, M., Moghimi, S., Safavi, M., Shafiee, A., Foroumadi, A.

Z. Naturforsch. B71(3):205-210 (2016).

 

  1. Design, preparation, and in vitro characterization of a trimodally-targeted nanomagnetic onco-theranostic system for cancer diagnosis and therapy.

Zarrin, A., Sadighian, S., Rostamizadeh, K., Firuzi, O., Hamidi, M., Mohammadi-Samani, S., Miri, R.

Int. J. Pharm. 500(1-2):62-76 (2016).

 

  1. Structure-activity relationship studies of 4-methylcoumarin derivatives as anticancer agents.

Miri, R., Nejati, M., Saso, L., Khakdan, F., Parshad, B., Mathur, D., Parmar, V.S., Bracke, M.E., Prasad, A.K., Sharma, S.K., Firuzi, O.* (*Corresponding author)

Pharm. Biol. 54(1):105-110 (2016).

 

  1. Cytotoxic and multidrug resistance reversal activities of novel 1,4-dihydropyridines against human cancer cells.

Shekari, F., Sadeghpour, H., Javidnia, K., Saso, L., Nazari, F., Firuzi, O.*, Miri, R. (*Corresponding author)

Eur. J. Pharmacol. 746(5):233-214 (2015).

 

  1. Modulation of neurotrophic signaling pathways by polyphenols.

Moosavi F., Hosseini R., Saso L., Firuzi O.* (*Corresponding author)

Drug Des. Devel. Ther. 21(10):23-42 (2015).

 

  1. Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors.

Silva, T, Borges, F., Edraki, N., Alizadeh, M., Miri, R., Saso, L., Firuzi, O.* (*Corresponding author)

RSC Advances 5(72):58902-58911 (2015).

 

  1. Inhibition of Alzheimer’s BACE-1 by 2,6-dialkyl-4-chromon-3-yl-1,4-dihydropyridine-3,5-dicarboxylates.

Razzaghi-Asl, N., Aggarwal, N, Srivastava, S., Parmar, V.S., Prasad, A.K., Miri, R., Saso, L., Firuzi, O.* (*Corresponding author)

Med. Chem. Res. 24(8):3230-3241(2015).

 

  1. Synthesis and cytotoxic activity of novel poly-substituted imidazo[2,1-c][1,2,4]triazin-6-amines.

Akbarzadeh, T., Noushini, S., Taban, S., Mahdavi, M., Khoshneviszadeh, M., Saeedi, M., Emami, S., …, Firouzi, O., Miri, R., Shafiee, A., Foroumadi, A.

Mol. Divers. 19(2):273-281(2015).

 

  1. Synthesis and cytotoxic activity of some novel dihyrobenzo[h]pyrano [3,2-c]chromene derivatives.

Esmati, N., Foroughian, M, Saeedi, M., Mahdavi, M., Khoshneviszadeh, M., Firuzi, O., Tanideh, N., Miri, R., Edraki, N., Shafiee, A., Foroumadi, A.

J. Heterocyclic Chem. 52(1):97-104 (2015).

 

  1. N-(2-(Piperazin-1-yl)phenyl)arylamide derivatives as β-secretase (BACE1) inhibitors: simple synthesis by Ugi four-component reaction and biological evaluation.

Edraki, N., Firuzi, O., Fatahi, Y., Mahdavi, M., Asadi, M., Emami, S., Divsalar, K., Miri, R, Iraji, A., Khoshneviszadeh, M., Firoozpour, L., Shafiee, A., Foroumadi, A.

Arch. Pharm. (Weinheim). 348(5):330-7 (2015).

 

  1. Inhibitors of Alzheimer's BACE-1 with 3, 5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridine structure.

Miri, R., Firuzi, O., Razzaghi-Asl, N., Javidnia, K., Edraki, N.

Arch. Pharm. Res. 38(4):456-69 (2015).

 

  1. Pharmacological applications of antioxidants: lights and shadows.

Saso, L., Firuzi, O*. (*Corresponding author)

Curr. Drug Targets. 15(13):1177-99 (2014).

 

  1. Cytotoxic activity assessment and c-Src tyrosine kinase docking simulation of thieno[2, 3-b] pyridine-based derivatives.

Nikkhoo, A. R., Miri, R., Arianpour, N., Firuzi, O., Ebadi, A., Salarian, A. A.

Med. Chem. Res. 23 (3):1225-33 (2014).

 

  1. Novel 9-(alkylthio)-acenaphtho[1, 2-e]-1, 2, 4-triazine derivatives: Synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2).

Mohammadi, M. K., Firuzi, O., Khoshneviszadeh, M., Razzaghi-Asl, N., Sepehri, S., Miri, R.

Daru. 6;22(1):2(2014).

 

  1. Synthetic approaches towards the sulfonamide substituted-1, 5-diarylimidazole-2-thiones as selective cyclooxygense-2 inhibitors.

Navidpour, L., Amini, M., Miri, R., Firuzi, O., Tavakkoli, M., Shafiee, A.

J. Heterocyclic Chem. 51(1):71-79 (2014).

 

  1. Oxidative aromatization, cytotoxic activity evaluation and conformational study of novel 7-aryl-10, 11-dihydro-7h-chromeno [4, 3-b]quinoline-6, 8(9h, 12h)-dione derivatives.

Motamedi, R., Shafiee, A., Rezai, M. R., Firuzi, O., Edraki, N., Miri, R.

Iran J. Pharm. Res. 13(1):103-14(2014).

 

  1. Cytotoxic, antioxidant and antimicrobial effects of nine species of woundwort (Stachys) plants.

Jassbi, A. R., Miri, R., Asadollahi, M., Javanmardi, N., Firuzi, O.* (*Corresponding author)

Pharm. Biol. 52(1):62-7 (2014).

 

  1. Carthamus,SalviaandStachysspecies protect neuronal cells against oxidative stress-induced apoptosis.

Tavakkoli, M., Miri, R., Jassbi A. R., Erfani, N., Asadollahi, M., Ghasemi, M., Saso, L., Firuzi, O.* (*Corresponding author)

Pharm. Biol. 52(12):1550-1557 (2014).

 

  1. Antioxidant and cytotoxic activities of the essential oil and extracts ofanisosciadium orientale.

Masroorbabanari, M., Miri, R., Firuzi, O., Jassbi, A.R.

J. Chem. Soc. Pak. 36(3):457-461 (2014).

 

  1. 4-Methylcoumarin derivatives with anti-inflammatory effects in activated microglial cells.

Togna, A. R., Firuzi, O., Latina, V., Parmar, V. S., Prasad, A. K., Salemme, A., Togna, G. I., Saso, L.

Biol. Pharm. Bull. 37(1):60-6 (2014).

 

  1. Antioxidant properties of hydroxycinnamic acids: a review of structure-activity relationships.

Razzaghi-Asl, N., Garrido, J., Khazraei, H., Borges, F., Firuzi, O.*

Curr. Med. Chem. 20(36):4436-50 (2013). (*Corresponding author)

 

  1. Cytotoxic, Antioxidant and Antimicrobial activities and phenolic contents of eleven Salvia species from Iran.

Firuzi, O., Miri, R., Asadollahi, M., Eslami, S., Jassbi, A. R.

Iran. J. Pharm. Res. 12(4):801-810 (2013).

 

  1. Design and synthesis of novel 3, 5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1, 4-dihydropyridines as small molecule BACE-1 inhibitors.

Razzaghi-Asl, N., Firuzi, O., Hemmateenejad, B., Javidnia, K., Edraki, N., Miri, R.

Bioorg. Med. Chem. 21(22):6893-909 (2013).

 

  1. Reversal of multidrug resistance in cancer cells by novel asymmetrical 1, 4-dihydropyridines.

Firuzi, O., Javidnia, K., Mansourabadi, E., Saso, L., Mehdipour, A. R., Miri, R.

Arch. Pharm. Res. 36(11):1392-402 (2013).

 

  1. Design, synthesis and biological evaluation of novel anti-cytokine 1, 2, 4-triazine derivatives.

Khoshneviszadeh, M., Ghahremani, M. H., Foroumadi, A., Miri, R., Firuzi, O., Madadkar-Sobhani, A., Edraki, N., Parsa, M., Shafiee, A.

Bioorg. Med. Chem. 21(21):6708-6717 (2013).

 

  1. Polyoxygenated cinnamoylcoumarins as conformationally constrained analogs of cytotoxic diarylpentanoids: Synthesis and biological activity.

Molaverdi, F., Khoobi, M., Emami, S., Alipour, M., Firuzi, O., Foroumadi, A., Dehghan, G., Miri, R., Shaki, F., Jafarpour, F., Shafiee, A.

Eur. J. Med. Chem. 8(68):103-110 (2013).

 

  1. Cytotoxic activity assessment, QSAR and docking study of novel bis-carboxamide derivatives of 4-pyrones synthesized by Ugi four-component reaction.

Shahrisa, A., Esmati, S., Miri, R., Firuzi, O., Edraki, N., Nejati, M.

Eur. J. Med. Chem. 66:388-99 (2013).

 

  1. Essential oil composition and cytotoxic activity ofDucrosia anethifoliaandDucrosia flabellifoliafrom Iran.

Shahabipour, S., Firuzi, O., Asadollahi, M., Faghihmirzaei, E., Javidnia, K.

J. Ess. Oil Res. 25(2):160-63 (2013).

 

  1. Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors of β-Secretase (BACE1).

Edraki, N., Firuzi, O., Foroumadi, A., Miri, R., Madadkar-Sobhani, A., Khoshneviszadeh, M., Shafiee, A.

Biororg. Med. Chem. 21(8):2396-2412 (2013).

 

  1. Synthesis and antiproliferative activity evaluation of imidazole-based indeno[1, 2-b]quinoline-9, 11-dione derivatives.

Sarkarzadeh, H., Miri, R., Firuzi, O., Amini, M., Razzaghi-Asl, N., Edraki, N., Shafiee, A.

Arch. Pharm. Res. 36(4):436-47 (2013).

 

  1. Effects of omega-3 polyunsaturated fatty acids on heart function and oxidative stress biomarkers in pediatric patients with dilated cardiomyopathy.

Firuzi, O., Shakibazad, N., Amoozgar, H., Borzoee, M., Abtahi, S., Ajami, G., Ardi, P., Miri, R.

Int. Cardiovasc. Res. J. 7(1):8-14 (2013).

 

  1. 2H-chromene derivatives bearing thiazolidine-2, 4-dione, rhodanine or hydantoin moieties as potential anticancer agents.

Azizmohammadi M., Khoobi M., Ramazani A., Emami S., Zarrin A., Firuzi O., Miri R., Shafiee A.

Eur. J. Med. Chem. 2(59C):15-22 (2013).

 

  1. Synthesis, biological activity and docking study of some new isatin Schiff base derivatives.

Azizian, J., Mohammadi, M. K., Firuzi, O., Razzaghi-asl, N., Miri, R.Med.Chem. Res. 21(11):3730-3740 (2012).

 

  1. Synthesis of ninhydrin derivatives and their anticancer, antimicrobial and cholinesterase enzymes inhibitory activities.

Ghalib, R.M., Hashim, R., Mehdi, S. H., Sulaiman, O., Pereira Silva, P. S., Jassbi, A. R., Firuzi, O., Kawamura, F., Chan, K. -L., Murugaiyah, V.

Lett. Drug Des. Discov. 9(8):767-74 (2012).

 

  1. Antioxidant activity assay based on the inhibition of oxidation and photobleaching of l-cysteine-capped CdTe quantum dots.

Hemmateenejad, B., Shamsipur, M., Khosousi, T., Shanehsaz, M., Firuzi, O.

Analyst. 137(17):4029-36 (2012).

 

  1. Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress.

Garrido, J., Gaspar, A., Garrido, EM., Miri, R., Tavakkoli, M., Pourali, S., Saso, L., Borges, F., Firuzi, O.* (*Corresponding author)

Biochimie. 94(4):961-7 (2012).

 

  1. Alterations in oxidative stress biomarkers associated with mild hyperlipidemia and smoking.

Miri, R., Saadati, H., Ardi, P., Firuzi, O.* (*Corresponding author)

Food Chem.Toxicol. 50(3-4):920-6 (2012).

 

  1. Antiradical and antioxidant activities of new bio-antioxidants.

Kancheva, V. D., Saso, L, Angelova, SE, Foti, M. C., Slavova-Kasakova, A., Daquino, C., Enchev, V., Firuzi, O., Nechev, J.Biochimie.94(2):403-15 (2012).

 

  1. Synthesis, Cytotoxicity, and QSAR Study of New Aza-cyclopenta[b]fluorene-1, 9-dione Derivatives.

Miri, R., Firuzi, O., Peymani, P., Zamani, M., Mehdipour, A. A., Heydari, Z., Farahani M. M., Shafiee, A.

Chem. Biol. Drug Des. 79(1):68–75 (2012).

 

  1. Synthesis, cytotoxicity and calcium antagonist activity of novel imidazolyl derivatives of 1, 8-acridinediones.

Jamalian, A., Miri, R., Firuzi, O., Amini, M., Moosavi-Movahedi, A. A., Shafiee, A.

J. Iran. Chem. Soc. 8(4):983-991 (2011).

 

  1. Antioxidant Therapy: Current Status and Future Prospects.

Firuzi, O.*, Miri, R., Tavakkoli, M., Saso, L. (*Corresponding author)

Curr. Med. Chem. 18(25):3871-88 (2011).

 

  1. Synthesis and Cytotoxicity Study of New Cyclopenta [b] quinoline-1, 8-dione Derivatives.

Miri, R., Firuzi, O., Peymani, P., Nazarian, Z., Shafiee, A.

Iran. J. Pharmaceut. Res. 10(3):489-96 (2011).

 

  1. Synthesis and cytotoxic activity of novel benzopyrano[3, 2-c]chromene-6, 8-dione derivatives.

Shafiee, A., Motamedi, R., Firuzi, O., Meili, S, Mehdipour, A. R., Miri, R.Med.Chem. Res. 20:466-74 (2011).

 

  1. Chemical composition of the essential oil, total phenolic content and antioxidant activity inOriganummajoranal. (Lamiaceae) cultivated in Iran.

Alizadeh, A., Khosh-khui, M., Javidnia, K., Firuzi, O., Jokar, S. M.

Adv. Environ. Biol. 5(8):2326-31 (2011).

 

  1. Design, Synthesis and evaluation of cytotoxicity of novel chromeno[4, 3-b]quinoline derivatives.

Miri, R., Motamedi, R., Rezaei, M. R., Firuzi, O., Javidnia, A., Shafiee, A.

Arch. Pharm. (Weinheim) 344(2):111-8 (2010).

 

  1. Dietary phenolic acids and derivatives:Evaluation of the antioxidant activity of sinapic acid and its alkyl esters.

Gaspar, A., Martins, M., Silva, P., Garrido, E. M., Garrido, J., Firuzi, O.*, Miri, R., Saso, L., Borges, F. (*Corresponding author)

J. Agric. Food Chem. 58(21):11273-80 (2010).

 

  1. Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents.

Moradi, A., Navidpour, L., Amini, M., Sadeghian, H., Shadnia, H., Firouzi, O., Miri, R., Ebrahimi, S. E., Abdollahi, M., Zahmatkesh, M. H., Shafiee, A.

Arch. Pharm. (Weinheim) 343(9):509-18 (2010).

 

  1. Antioxidant properties of 4-methylcoumarins in in vitro cell-free systems.

Morabito, G., Trombetta, D., Singh, K., Prasad, K., Parmar, S., Naccari, C., Mancari, F., Saija, A., Cristani, M., Firuzi, O., Saso, L.

Biochimie 92(9):1101-7 (2010).

 

  1. Composition and biological activities of essential oils from fourHeracleumspecies.

Firuzi, O., Asadollahi, M., Gholami, M., Javidnia, K.

Food Chem. 122(1):117-22 (2010).

 

  1. Antioxidant activity and total phenolic content of 24 Lamiaceae species growing in Iran.

Firuzi, O.*, Javidnia, K., Gholami, M., Soltani, M., Miri, R. (*Corresponding author)

Nat. Prod. Commun. 5(2):261-4 (2010).

 

  1. Microwave-assisted solvent-free synthesis of bis(dihydropyrimidinone)benzenes and evaluation of their cytotoxic activity.

Azizian, J., Mohammadi, M. K., Firuzi, O., Mirza, B., Miri, R.

Chem. Biol. Drug Des. 75(4):375-80 (2010).

 

  1. Antimicrobial and antioxidant activity and chemical composition of the essential oil of tanacetummacrophyllum (Waldst. et Kit. )

Schultz. Bip. Javidnia, K., Gholami, M., Firuzi, O., Özer, H., Kandemir, A.

J. Ess. Oil Res. 22(2):186-8 (2010).

 

  1. Effects of fertilizer on yield, essential oil composition, total phenolic content and antioxidant activity inSatureja hortensisL. (Lamiaceae) cultivated in Iran.

Alizadeh, A., Khoshkhui, M., Javidnia, K., Firuzi, O., Tafazoli, E., Khalighi, A.

J. Med. Plant Res. 4(1):033-040 (2010).

 

  1. Protein oxidation markers in the serum and synovial fluid of psoriatic arthritis patients.

Firuzi, O., Spadaro, A., Spadaro, C., Riccieri, V., Petrucci, R., Marrosu, G., Saso, L.

J. Clin. Lab. Anal. 22(3):210-5 (2008).

 

  1. 5-lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease.

Firuzi, O., Zhuo, J., Chinnici, C. M., Wisniewski, T., Pratico, D.

Faseb J. 22(4):1169-78 (2008).

 

  1. Specific oxidative stress parameters differently correlate with nailfold capillaroscopy changes in systemic sclerosis.

Riccieri, V., Spadaro, A., Fuksa, L., Firuzi, O., Saso, L., Valesini, G.

Clin. Rheumatol. 27(2):225-30 (2008).

 

  1. Effect of infliximab on the glycosylation of IgG in patients with rheumatoid arthritis.

Croce, A., Firuzi, O., Altieri, F., Eufemi, M., Agostino, R., Priori, M, Valesini, G., Saso, L.

J. Clin. Lab. Anal.21:303-14(2007).

 

  1. Antioxidant and pro-oxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase.

Schmalhausen, E. V., Zhlobek, E. B., Shalova, I. N., Firuzi, O., Saso, L., Muronetz, V. I.

Food Chem. Toxicol. 45:1988-93 (2007).

 

  1. A Spectroelectrochemical and chemical study on oxidation of hydroxycinnamic acids in aprotic medium.

Petrucci, R., Marrosu, G., Astolfi, P., Firuzi, O., Saso, L., Greci, L.

Electrochim. Acta. 52:2461-70 (2007).

 

  1. Parameters of oxidative stress status in healthy subjects; their correlations and stability after sample collection.

Firuzi, O., Mladenka, P., Riccieri, V., Spadaro, A., Petrucci, R., Marrosu, G., Saso, L.

J. Clin. Lab. Anal. 20:1-10 (2006).

 

  1. Oxidative stress parameters in different systemic rheumatic diseases.

Firuzi, O., Fuksa, L., Spadaro, C., Boušová, I, Riccieri, V., Spadaro, A., Petrucci, R., Marrosu, G., Saso, L.

J. Pharm. Pharmacol. 58:951-7 (2006).

 

  1. Coxibs and Alzheimer’s disease: Should they stay or should they go?

Firuzi, O., Praticò, D.

Ann. Neurol. 59:219-28 (2006).

 

  1. Atractylisgummifera L. poisoning: an ethnopharmacological review.

Daniele, C., Dahamna, S., Firuzi, O., Sekfali, N., Saso, L., Mazzanti, G.

J. Ethnopharmacol. 97:175-81 (2005).

 

  1. Evaluation of the antioxidant activity of flavonoids by "ferric reducing antioxidant power" assay and cyclic voltammetry.

Firuzi, O., Lacanna, A., Petrucci, R., Marrosu, G., Saso, L.

Biochim. Biophys. Acta 1721:174-84 (2005).

 

  1. Hypochlorite scavenging activity of flavonoids.

Firuzi, O., Mladenka, P., Petrucci, R., Marrosu, G., Saso, L.

J. Pharm. Pharmacol. 56:801-7 (2004).

 

  1. Hypochlorite scavenging activity of hydroxycinnamic acids evaluated by a rapid microplate method based on the measurement of chloramines.

Firuzi, O., Giansanti, L., Vento, R., Seibert, C., Petrucci, R., Marrosu, G., Agostino, R., Saso, L.

J. Pharm. Pharmacol. 55:1021-7 (2003).

 

  1. Development of a new assay for the screening of hypochlorous acid scavengers based on reversed-phase high performance liquid chromatography.

Gatto, M. T., Firuzi, O., Agostino, R., Grippa, E., Borsò, A., Spinelli, F., Pavan, L., Petrolati, M., Petrucci, R., Marrosu, G., Saso, L.

Biomed. Chromatogr. 16:404-11 (2002).